RAF Typhoon FGR4s have conducted a mission with France's air force in a combined operation targeting an subterranean weapons facility in Syria employed by the Daesh militant organization, according to the UK's MoD.
The site, identified by reconnaissance, was assessed as containing munitions and bombs, the statement said, and was positioned in hills just north of the ancient city of Palmyra in central Syria.
"Our fighter planes used precision-guided Paveway IV munitions to hit a several approach shafts providing entry to the facility... initial indications are that the strike was effective," the MoD said.
There was no indication of any harm to civilians in the attack on Saturday evening and every plane involved returned safely, the ministry further stated.
The Typhoon fighters were backed up by a Voyager refuelling tanker.
IS - also known as Daesh - established jihadist rule over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This strike shows our UK leadership, and resolve to operate in unison with our allies, to stamp out any resurgence of Daesh and their harmful and extremist ideologies in the area," Britain's Defence Chief John Healey said.
British military aircraft have carried out patrols over Syria to "prevent any attempted comeback" of the group after its defeat at the climactic battle in Baghuz in 2019, the ministry said.
"I extend gratitude to the personnel of the UK armed forces involved in this operation for their skill and their bravery," he said. "They were part of a great many British personnel deployed over Christmas and New Year. This action, to take out terrorist threats who endanger our way of life, shows how our armed forces are ready to step up, throughout the year, protecting the UK domestically and strong abroad."
During December, the American forces executed what it described as a "massive strike" on IS targets in Syria, after an assault resulted in the deaths of two US servicemembers and a civilian interpreter in the Palmyra area.
The U.N. says Islamic State still has roughly 5-7 thousand fighters in both countries.
